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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e611794eb8b9eaff0c2ba144b1e2b1b63d6e7da99278972ee807bf2c26d0b552' 
  AND token = 'thU7/Cz3jtLP024MN2HlIXGLBh25BO9azYUVFqHdqgI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}