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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d48ec89f7fccd5cdbe16ba907ac0ed133dcc3a33acf625230b4ac3888251295' 
  AND token = 'MR14KgDA+BzYbtFk76GPyVeNAFnCjBlyI5jTji9GWmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}