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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50fcef937ecfe5a5813fc18b51a5f0e22ca8affa31c6ccf3edecf3b99e629d8a' 
  AND token = 'yotH0E05a88lKvPqr3WuOpn+uETPX+f4mshXBBrCaAM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}