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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1545e88b83e4516bc5cbc37a020f338a47a286fe6db14d7a8ba2ba396a43748' 
  AND token = 'p4bzpp31g2e54I7THeUxXcvW1+oU4oI5yNb4LEXSdGg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}