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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78113c1252b365408936c3db2c5bf069107abfe7e74acc35fa85a8a3a20144cd' 
  AND token = 'MIIzWanvHmhBum8vb5pSbT67goh+TmHrF17zt7R8CwU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}