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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10d11eb7979251c690017b807e7d773e4647987979389019089aae1f04d4216c' 
  AND token = 'woi8SG71oHtOxc6Mb7zS6x+vqCMKtcrmVEycZJGIZbg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}