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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3cd81d4efa7e6977012c151d06713b507465b9e4dde145e3546c48e965c173a6' 
  AND token = 'va3nXIk7DNYgcbx5kAgBj0oK0H7hGY1CeBMbm/TRSIA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}