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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42b8032eeca63c386463b4d6a58e4d1ecac633daada7909b506448b28a282709' 
  AND token = 'iHFUIv1a/su1w3v/V18HtLeAT0Xygxzp1ldCn1jxduU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}