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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1043e2df74fc736e3c8eea98fce6fc05fcffe7aab4419cf2ceeddadbe4d6533c' 
  AND token = 'hrudtYI7OgP39HfJgvPcLk5L5olKBAfowsfjmNwYL0E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}