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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '743101e55dab10363f408b6181459664b118565cefc55347801db679bb9ca211' 
  AND token = 'zx5USppHSJMfHwCv2muwdwPhlba4yvreE+sm89I016g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}