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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '250eb507344a386515365d278202988f9aa05f0e5906ae4e14ee575c022726cc' 
  AND token = 'nwKXYyJHwsLZ6pG3Rwz6YQFz32gbm4r/KthHtKY7sRc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}