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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '643e5a9daecfbc9d80d16d39ed201aa249fa2d7f4d23b9ce154f5e45c9926f9f' 
  AND token = 'bD12fMoRiOBGhKSNLr39lFbZCBGzaWLMiIQZenV6uTo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}