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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a227cb52b4f01bad0f5ace39c8a4db11a18a3c624b02c736bd425950397badf9' 
  AND token = '7KkEomUaoBBzgEfZy6y/saHtKXpfdhwq8SBtoTWiri4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}