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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c78b642e31118b9929ebecab333c846315a73548a8e6f8d0122453b35f96296b' 
  AND token = '0NlV2Hl4eiRjdzSA6kWAuuKJi7qVKmyb3UIz0+/FEYc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}