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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9e8e78b2c3f83f3901a2853c206a6764ee339c19fdb1e11f3adb623ab301ee00' 
  AND token = 'HDtZ6GpvtSmAZlgH79n/gkBwixZsKqFwfSKfXJZuaA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}