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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5d6d17d34303511f3a8a1e4ed1c07fdc21805a0000b9372aed705436c884a46' 
  AND token = 'nFxJWPec4iX4Y1GVzM++7OWkZNaiMDQBM/eHueSfyQM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}