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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2849cb25c6efd4b456e6e49cd92dd4851fdb31c8f38f047ae1663000d6cd6689' 
  AND token = 'iR7i474Gutnf3It9QLcFrYt1MUFeGvKvPYh+lfRZ06I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}