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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ffa5db81afabf26ed287626d0251ab639f4c6e7388d4e7352a8fb1dcddd8b072' 
  AND token = 'VLVyL8C72qn+7u4FkgOv8mNwVT6VrYWUB8OVXCV5hqo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}