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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8e4b9cba48da1a031f5d8d88de82b17777dee0197c8b60a40c7dd728fbd39b7' 
  AND token = '1WE0F+jFaVcoaSIT7pNoo4fx3vKlmNWIXiveRwpFjkI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}