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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49658a480bbb65fe66deaf3713d1a0a5235a1eafe53305e1d80a0c1b47428656' 
  AND token = 'NfrSK6+YvXWcbZDq3/q/UB7XkBeucuy4PQJ5xDBgyvM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}