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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9de3d8af8d97436af5846031855aabd1e37e8a19f1645b06880d8b48e7fbe61d' 
  AND token = '8USjL4Do4fygPnmQE1sefsYhh9dRxgBAxVRLR5qBQrI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}