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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '40b225666f7e4b265c679575905e069dbd393ae9fd9e8bd81148f299bb5a768b' 
  AND token = 'JUSac1E0vs2DdUhFsDVxx9c5f5pRd6RzY44uOYM4MNQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}