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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ba8a9f4d7062cac533c020d207609a05f8654112a9f3948b8722aa6ef0204e' 
  AND token = 'dD8G2hk9I8OqydzkhBy7QgQEBSRm+aPiRLGChnB6Bo4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}