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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '753c237df1a44bd6c5a336a9bea93787602b2c7dfa4a5597c7162a456b99aa48' 
  AND token = 'wH+ydosme8qhAD2U35ZuPzzhN/6mSy/3Dgc/nAyVRzI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}