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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1b644cf5e02001aad4ea7cd3137dc3aac6b3af777add133eddace04419842c2' 
  AND token = 'qmSJ/W8olyXcgSWS+0/zaNITYTqBxvjNC7wYBx9pnoY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}