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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '287a7579383d05220fe728590646aa81b5a24a836be0af9fb6fcea19fdf557a2' 
  AND token = 'taLj4xha5duFgn+zqwxCQLVE+EKcAlZ3oSFxYd5xSNg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}