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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '354b1f889186d23b0607531dd3b491e486b5b5fc7b161e8e6b7077d3aa6abb01' 
  AND token = 'LN4LjeITQAUJCamILoCaNGwxbNEGs3ohcaaNgA5FGLI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}