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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b603ac6d1a4501721cfa411d8405154a5d429f8e53281aff760f8f4c6a83a87' 
  AND token = 'CTAHOdLN0mg+q4ocQ5fXwO83N8j/9V/G9xtSDTHRcTs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}