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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c2b47b73d1d3fe11d6d09107545c24780f4689fd246413c5ba29e22aa352e410' 
  AND token = 'ET9d+AAN9e/QiGWj+xMsnNttMOaasR/lLe1ZEgBv0CQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}