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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f16ec1cfbc250bd5a1e6156e7d3115ec5c8a9ec59d99970b2e53be052190601' 
  AND token = 'vruqOeIohmqtyTNkH9/h7uGGmD4xerQnNt72I3w21Po=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}