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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4022ae0f48b1fa3ef6ae75aa4a80837e6d1c204b270794dec33829c45ea32262' 
  AND token = 'hmZYeuOUa5f1JAQNEJ1jV9ptbWUlq0MeSMKQddwpBtM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}