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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45d2216bfc8a795464a3d80fb26de6ceb8b9091e3a5b60ff298b2e1383d181a0' 
  AND token = 'IF/2IKFMY8tyij6AKS4gFdVjREImVq3I2Ci+MSGskKQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}