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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d840d47ce091863cd226d37bc8f50de5c99f54d5be239ca77aef983e8f6b139' 
  AND token = 'afuMgQLTwIT/jvHOXTI5E8v1vFAMDtjkpFupguNNA5U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}