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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '790ee0452d4daaa093eab5afff6db15b272d9a70eb4f9f31e506e1c7ccff5ed2' 
  AND token = 'AMq7rcz0RDA/LgDipS01kOMSKPgfVNwVMIasWCamGvI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}