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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad9299bf3957576f36c4b8c5fc62499f20d60715e07c14eeff36d37a4bc5b1bf' 
  AND token = 'ywMTeFhEK9ByfJIAp/I261i/bYuW2Zf9xuTdnkaxFXs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}