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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4c9f009dde021003db54bec854eed32efee38e1862f68dadc0f4fe98e0efaf9' 
  AND token = 'SFmsqXT5gTSWGm+N7nbmc4vlriPDyNIU8Z/bxhhIXPI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}