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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '180e0437fcf0e65c8e540777d12ee27662c69945bffe7f1404813876dcf85291' 
  AND token = 'IvXwECbL79Is6MXTl6nZ00sDGKdajutK7RbAfqTzvYY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}