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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '87544c527ad373da9225e5a22d6e0a5242611b50eafe039e86bfe7db21c6650e' 
  AND token = 'z4ncGXa9zKhQdWKeZX3uiqcIZcnsInHjVJGUwzXT9bA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}