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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ecc78b0228d3b605fd95bb3864d04be0dded6dc21bd5f35e3a333f402785b62' 
  AND token = '+B41LKHF29sP/7ssL46AbXY4jO0EYS3oyxkS4Cxb6mE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}