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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d3aff90871b5f0e2be3042b2b5b2c854fc594a73715795b1094a48643fa9584' 
  AND token = 'zZ8Pf/6bhBq5HmPfcmwMlcJo2kCpB8ZttCqU45IvtIQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}