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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a154daa6da298527d2d2dfe37be0bc229f3ffc1db5809995002b4985e29c842' 
  AND token = 'KDG4sD/7Ic9hl7IFgtkAwju8kyWX361MDN7Z5zrk9wo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}