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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8072ac57d09c8b23d55f9959c2f4179dc1e18f99725674caee80a781853b6789' 
  AND token = 'Yc1h4qQTXnL+1bdQDJSWKSI2E/GLMkW8C1AaxwNvKvE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}