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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b333612ecbfd8c6a398b5b57cc9024f6a507de21e95cb95980688c51fdd496c8' 
  AND token = 'C6euVjrx8ju5qDL0uKQIfgUUtXfFNFb7wG2ADDcIVXQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}