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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4404f16f829d18599a29f2602f7c8849eab1e78a19b1ce38193f539464c3557a' 
  AND token = 'aVsfiiilg5YbJkz5D5i5qJR2wFmUEbuyIdHxTXRL9sM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}