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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c33b880a24d668937157c1ac8b8f683c1ea35ebd9be111a3e19c8dc0dca5674e' 
  AND token = 'NZa3A4tclTRdi0L8NkRyD7QK7e3oyrsNp1cB4ZcmJK4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}