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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d189c3fe720b7e336cce4f8af9712cfb43fe5d0d2bed025aa674d5c57190861' 
  AND token = 'DG4E1BHZMkJiotKU3GaYfZRwZikRBYRbU6j01WE2mkM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}