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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c53ce70731afcb2dac54b3b90f9fdc76206e0981a00b0f2413787e0325fe672' 
  AND token = 'JUEvANzB+1DPBscYx3iqgvJ74G9fjPXQPyg0U9oF7f4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}