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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b2771a275fa3b5247ac7ae5fe0826f31c50a235495c050d0cb5e431bdc46ea58' 
  AND token = 'VphnbI+Gt5CsaQ2rEm9FdOSVXLpWD4XpB16Hlly2LR0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}