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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81a8f2dc5d306758320834ec66848e65140f4f3d049df17ce2e96c21f899ca57' 
  AND token = 'EcoyfKlxGZ9DgqNG1QdNzh14/1OJ5reU/DxRS49N/sg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}