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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8078290574eba485bcb0b90463b4a656fbc76dd8f52e097265ec980c33c55b0' 
  AND token = 'jevxM9Ycyki5CAnBxvS+gwsY+xYmZZZiT2zcRIYktpA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}